【摘 要】
：
Background Patients of chronic hepatitis B with acute exacerbation were usually followed by a spontaneous decline of HBV DNA.The subsequential antiviral therapy are controversial.In this study, we eva
【机 构】
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The Third Affiliated Hospital of Sun Yat-Sen University
【出 处】
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中华医学会第十六次全国病毒性肝炎及肝病学术会议
论文部分内容阅读
Background Patients of chronic hepatitis B with acute exacerbation were usually followed by a spontaneous decline of HBV DNA.The subsequential antiviral therapy are controversial.In this study, we evaluated the efficacy and safety of peginterferon alfa-2a for patients of chronic hepatitis B with spontaneous decline of HBV DNA after acute exacerbationMethods Forty-three patients with spontaneous decline of HBV DNA (a decrease of HBV DNA levels of more than 2 log (10) IU/mL as compared to baseline before antiviral treatment) after acute exacerbation (ALT was 10-30ULN, TBIL was 2-20mg/ml, PTA ＞ 60％) were included.All of them were positive for HBeAg.Twenty-two patients (group1) accepted peginterferon alfa-2a (180 ug/kg/week, when ALT was ＜ 10 ULN, TBIL ＜ 2mg/ml) for 48 weeks, with 24 weeks of treatment-free follow-up.Twenty-one patients (group2) accepted continual entecavir therapy at enrollment.The virologic, serologic and biochemical factors at 72 were compared.
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