【摘 要】
：
目的 应用神经毒素鱼藤酮建立稳定的帕金森病(PD)SD大鼠模型,观察白藜芦醇苷对PD的神经保护作用,探讨其作用机制.方法 大鼠背部sc给予鱼藤酮2.0mg· kg-1,持续5周,制备模
【机 构】
：
南方医科大学药学院药理学系,广东广州510515
【出 处】
：
第十四届中国神经精神药理学学术会议
论文部分内容阅读
目的 应用神经毒素鱼藤酮建立稳定的帕金森病(PD)SD大鼠模型,观察白藜芦醇苷对PD的神经保护作用,探讨其作用机制.方法 大鼠背部sc给予鱼藤酮2.0mg· kg-1,持续5周,制备模型.SD大鼠随机分为6组：空白对照组,模型组(仅注射鱼藤酮),鱼藤酮+左旋多巴10mg· kg-1组,鱼藤酮+白藜芦醇苷20,40,80 mg· kg-1组,左旋多巴和白藜芦醇苷均通过ig给药,并持续给药5周.
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