Understanding agonism,antagonism and activation of aminergic GPCRs--Drug design targeted at dopamine

来源 :第十三届全国计算机化学学会会议 | 被引量 : 0次 | 上传用户：fiveboy0714

【摘要】

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【作者】

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Wei Fu

【机构】

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Department of Medicinal Chemistry & Key Laboratory of Smart Drug Delivery,Ministry of Education,Scho

【出处】

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第十三届全国计算机化学学会会议

【发表日期】

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2015年7期

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As the largest family of integral membrane proteins,G-protein-coupled receptors(GPCRs) comprise the largest class of therapeutic targets that aimed by approximately 45 ％of modern medicinal drugs.Therefore,understanding the signal transduction,as well as the agonist/antagonist mechanism of the GPCRs,is pivotal in drug discovery and new therapeutic strategy development.

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Understanding agonism,antagonism and activation of aminergic GPCRs--Drug design targeted at dopamine

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