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In tumor microenvironment,interactions among multiple cell types are critical for cancer progression.Secreted proteins are responsible for crosstalk among these cells within tumor microenvironment.To elucidate the interactions of tumor and epithelia,we co-cultured colon cancer cell line HT29 with normal human colon mucosal epithelial cell line NCM460 to mimic tumor microenvironment in vitro and investigated the differential expression pattern of secretome.