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Purpose:To compare promoter polymophrisms of matrix metalloproteinases-3(MMP-3)(rs3025058)and interleukin-6(IL-6)(rs1800795)genes in Adolescent Idiopathic Scoliosis(AIS)of different gender Methods:we conducted a case-control study to explore whether promoter polymophrisms of MMP-3 and IL-6 were different in AIS of different gender,the same time to confirm the association between gene variants of MMP-3 and IL-6 and AIS.