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5. Inducible huntingtin knockout mice reveal age-and cell type-dependent vital function of huntingtin a

Inducible huntingtin knockout mice reveal age-and cell type-dependent vital function of huntingtin a

来源 :The 6th FAONS Congress and 11th Biennial Conference of CNS(第 | 被引量 : 0次 | 上传用户：jianrui02

【摘 要】

：

The Huntington disease(HD)protein,huntingtin(Htt),is essential for early development.Since suppressing mutant htt expression becomes an important approach to treat HD,understanding the normal function

【作 者】

：

Guohao Wang Xudong Liu Marta A.Gaertig Scott Zeitlin Shihua Li Xiao-Jiang Li 

【机 构】

：

State Key Laboratory of Molecular Developmental Biology,Institute of Genetics and Developmental Biol

【出 处】

：

The 6th FAONS Congress and 11th Biennial Conference of CNS(第

【发表日期】

：

2015年3期

【关键词】

：

Huntington’s disease conditional htt-KO mouse age-dependent acinar cell Spink3 t 

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论文部分内容阅读

　　The Huntington disease(HD)protein,huntingtin(Htt),is essential for early development.Since suppressing mutant htt expression becomes an important approach to treat HD,understanding the normal function of htt in adulthood is imperative for developing effective treatments.

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