2. 您的位置
3. 首页
4. 会议论文
5. Transcriptomic changes associated with PCK1 overexpression in hepatocellular carcinoma cells detecte

Transcriptomic changes associated with PCK1 overexpression in hepatocellular carcinoma cells detecte

来源 :2019中国肿瘤学大会 | 被引量 : 0次 | 上传用户：fjnu_lhx

【摘 要】

：

Objective Liver cancer is the fourth cause of cancer death worldwide in 2018,with about 841,000 new cases and 782,000 deaths annually.Hepatocellular carcinoma(HCC)comprises 75%-85%of primary liver can

【作 者】

：

jin xiang Yuhong Zhang Lin Tuo Rui Liu Dongmei Gou Li Liang Chang Chen Jie Xia Ni Tang Kai Wang 

【机 构】

：

Key Laboratory of Molecular Biology for Infectious Diseases(Ministry of Education),Institute for Vir

【出 处】

：

2019中国肿瘤学大会

【发表日期】

：

2019年7期

【关键词】

：

phosphoenolpyruvate carboxylase kinase1 (PCK1) hepatocellular carcinoma cells RN 

下载到本地 , 更方便阅读

下载此文 赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Objective Liver cancer is the fourth cause of cancer death worldwide in 2018,with about 841,000 new cases and 782,000 deaths annually.Hepatocellular carcinoma(HCC)comprises 75%-85%of primary liver cancer and lacks effective treatment measures.

其他文献

THAP7 promotes cell proliferation by regulating G1/S phase via epigenetically silencing p21 in lung

Objective Lung cancer still remains the leading cause of cancer-related deaths worldwide.About 85%of the lung cancers are non-small-cell lung cancer,including squamous cell carcinoma,adenocarcinoma,an

会议

THAP7lung adenocarcinomacell proliferationcell cycle

RUNX1 contributes to the mesenchymal subtype of glioblastoma in a TGFβ pathway-dependent manner

Objective Runt-Related Transcription Factor 1(RUNX1)is highly expressed in the Mes subtype of glioblastoma(GBM).The transforming growth factor-β(TGF-β)signaling pathway has been associated with a vari

会议

RUNX1TGFβtranscription protein complexmesenchymalglioblastoma

Hsa_circ_0003998 may be used as a new biomarker for the diagnosis and prognosis of hepatocellular ca

Objective Circular RNAs(circRNAs)play important roles in the progression of cancers,but the precise role of circRNAs in the diagnosis and prognosis of hepatocellular carcinoma(HCC)remains to be clarif

会议

hepatocellular carcinomacircular RNAhsa_circ_0003998biomarkerdiagnosisprogn

靶向去泛素化酶UCH37治疗恶性脑胶质瘤的分子机理研究

目的 脑胶质瘤是最常见的原发神经系统恶性肿瘤，治疗困难，患者预后极差，急需寻找新的治疗方案。去泛素化酶广泛参与肿瘤增殖、侵袭等恶性进程，是潜在的抗肿瘤靶点。本项目旨在研究去泛素化酶UCH37 在胶质瘤中的核心功能和作用机制，探讨其抑制剂治疗胶质瘤的潜能。

会议

胶质瘤去泛素化酶UCH37细胞凋亡b-AP15

Prevalence and Clinical Features of Germline Variants in DNA-Repair Pathway Genes in 2353 Unselected

Objective DNA-repair pathway genes play an important role in the etiology and progression of breast cancer.BRCA1/2,along withPALB2,CHEK2,andRECQL,is the most commonly mutated genes in hereditary breas

会议

Germline VariantsDNA-Repair PathwayGenesBreast Cancer

Degradation of Cyclin D1 Protein by Multiple Cullin-Associated E3 Ligases in Cancer Cells

Objective The half-life of Cyclin D1 is about 30 minutes,which is under the tightly control of ubiquitin-proteasomal degradation mechanism during cell cycle progression.

会议

Cyclin D1ubiquitinaitonESCCCullin-Ring E3 ligase

Novel prognostic biomarkers of gastric cancer based on gene expression microarray:COL12A1,GSTA3,FGA

Objective Gastric cancer(GC)is the fifth most common malignancy in the world,especially in developing countries.GC has been the leading cause of cancer death worldwide until the mid-1990s,after which

会议

Gastric cancerBiomarkerDifferentially expressed genesProtein-protein interact

Mir-16a/adrb2通过MAPK/Erk调节肝癌复发转移的机制研究

目的 肝癌复发转移是当前肝癌治疗的重大难题,G蛋白偶联受体超家族(GPCR)是肝癌治疗的研究热点,与肿瘤的发生发展、代谢性疾病等重大疾病的主要机制息息相关。肾上腺素受体(ADR)是一种重要的GPCR 蛋白,ADR 信号通路在肿瘤复发转移中发挥着关键作用,研究表明β 2 肾上腺素受体(ADRB2)是肝癌细胞表面最重要的ADR,本研究拟聚焦于ADRB2 信号受体通路,阐明ADR2信号通路(β 2-AR

会议

肝癌β2受体复发转移

Cul4 E3 Ubiquitin Ligase Regulates Ovarian Cancer Drug Resistance by Targeting the Anti-apoptotic Pr

Objective Purpose: The failure of cancer chemotherapy is mostly caused by the development of drug resistance.In addition to the extensive genetic and epigenetic alterations in cancer cells,cancer cell

会议

ubiquitin ligasechemotherapyovarian cancerapoptosisdrug resistance

MIAT long noncoding RNA functions as a competing endogenous RNA to upregulate EZH2 by sponging miR-1

Objective While long noncoding RNAs(lncRNAs)have been reported to play an important role in regulating the pathological process of several human cancer types,they remain poorly understood in papillary

会议

Papillary thyroid carcinomaLong noncoding RNAceRNAMIATEZH2