Caveolae Contributes to Receptor-Operated Ca2+Entry in Aortas of 2K1C Hypertensive Rats

来源 :2016年国际生理学学术大会 | 被引量 : 0次 | 上传用户:ahclgc
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  Introduction: Caveolae are cholesterol enriched plasma membrane flask-shaped invaginations and has been regarded as a regulator of intracellular Ca2+concentration([Ca2+]i)signaling.We have previously found that the number of caveolae were increased significantly in pulmonary artery smooth muscle cell(PASMC)in pulmonary hypertension(PH)models and the increase in caveolae expression in PH contribute to the enhanced agonist-induced pulmonary arteries(PAs)contraction via receptor-operated Ca2+channels(ROCC)in PASMCs.
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