Laser-induced thermal therapy referred to as photothermal therapy employs laser light energy sources and provides a precise and minimally invasive alternative for treating inoperable tumors.However,current photothermal therapy is more effective in treating local cancer at the primary site than metastatic cancer.Near-infrared light-responsive inorganic nanoparticles such as CuS nanoparticles exhibit strong optical absorption,convert optical into thermal energy,and deposit benign optical energy in tumors for enhanced thermal ablation of tumor cells.Here,we use hollow CuS nanoparticles(HCuSNPs)with intense photothermal coupling effects to develop photothermal ablation-mediated cancer combinatorial therapy.We report the design of chitosan-coated HCuSNPs that assemble the immunoadjuvants oligodeoxynucleotides containing the cytosineguanine(CpG)motifs.