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PURPOSE: Polymethylmethacrylate(PMMA)is widely used for pedicle screw augmentation in osteoporosis.Intriguingly,therere no studies on screw stabilities augmented with different volumes of PMMA and relationship between screw stability and volume of PMMA in different bone condition.This study was designed to compare screw stabilities augmented with different volumes of PMMA,analyze relationship between screw stability and volume of PMMA and optimum volume of PMMA in different bone condition.