为了进一步增强膀胱癌组织特异性溶瘤腺病毒基因治疗的有效性,可以将肿瘤微环境作为靶点进行研究,有研究表明,细胞内外微环境的改变可以影响腺病毒载体的复制和凋亡相关蛋白的表达,同时在腺病毒侵染细胞的过程中,细胞会应激产生自由基活性氧和活性氮,由于自由基可作为一种第二信使分子参与细胞信号通路调控基因的表达,能改变细胞内氧化应激状态,从而调节细胞生长、增殖及凋亡过程,所以本研究观察在重组溶瘤腺病毒Ad/UP
目的 研究不同恶性程度的乳腺肿瘤病例中FRY 蛋白的表达情况及其与临床病理参数之间的关系.方法 采用自制的鼠抗人FRY 单克隆抗体,对收集的104例乳腺肿瘤病例(其中纤维囊性乳腺病11 例,不同分级的乳腺浸润性导管癌93例)中FRY 蛋白的表达情况进行免疫组化检测,比较FRY 蛋白表达情况与乳腺肿瘤恶性程度及不同临床病理参数之间的关系.结果 11 例纤维囊性乳腺病与93例乳腺浸润性导管癌病例中FR
Increasing evidence demonstrates that reactive oxygen species plays important roles in sepsis-induced acute kidney injury.This study investigated the effects of VitD3 pretreatment on renal oxidative s
Increasing evidence demonstrated that vitamin D had an anti-inflammatory activity.The aim of the present study was to compare the effects of calcitriol,the active form of vitamin D3,and cholecalcifero
Increasing evidence demonstrated that maternal vitamin D deficiency during pregnancy was linked with adverse pregnant outcomes.Nevertheless,the association between maternal vitamin D status during pre
It is increasingly recognized that vitamin D3(VitD3)has an anti-inflammatory activity.The present study investigated the effects of maternal VitD3 supplementation during pregnancy on LPS-induced place
Early pulmonary inflammation and epithelial-mesenchymal transition(EMT)play an important role in the pathogenesis of bleomycin(BLM)-induced lung fibrosis.Increasing evidence demonstrates that calcitri
Vitamin D deficiency is common in the pregnant women.The objective of this study was to investigate whether maternal vitamin D deficiency during pregnancy and the risks of small for gestational age(SG
Previous study showed that maternal urinary cadmium(Cd)level was negatively associated with birth weight.The present study evaluated the association between maternal serum Cd level and fetal growth re
Increasing evidence demonstrated that zinc(Zn)insufficiency during pregnancy was linked with adverse pregnant outcomes.The objective of this study was to investigate the association between maternal Z