Aryne is reactive intermediate in which a π bond is formed by overlapping two σ-orbitals on the ortho position of an arene.With the development of 2-(trimethylsilyl)aryl triflates as a modem precursor that can generate arynes under much milder conditions, arynes have evolved from simple reactive intermediate in the textbook to a useful reactant in synthetic chemistry.This talk will briefly summarize our recently developed methods that exploit aryne chemistry to constructing heterocycles.Progress on other directions of aryne chemistry will also be mentioned.