【摘 要】
：
The androgen receptor (AR) signaling axis has been the cornerstone of investigations into the prevention and therapy of metastatic prostate cancers (PCa).As
【机 构】
：
Agricultural Biotechnology Research Center Taiwan
论文部分内容阅读
The androgen receptor (AR) signaling axis has been the cornerstone of investigations into the prevention and therapy of metastatic prostate cancers (PCa).As recurrent tumors restore AR activity independent of hormones, new therapies that abolish AR activity have been sought to prevent or delay the emergence of hormone-refractory disease.To monitor the AR activity in PCa cell, we established a reporter cell line by stable transfection of human PCa 22Rv1 cells with a lueiferase reporter gene regulated by prostate-specific antigen (PSA) promoter.Using this system,, we identified through systematical purification from plants various phytocompounds that potently suppressed AR activity in PCa cells.
其他文献
The discovery and characterization of novel groups of proteins (cofactors) that participate in the transcriptional activity of nuclear receptors (NRs) have
11月1日晚,首创资产、白云生活广场、蓝图地产机构在翠宫饭店举行产品说明会,正式推出白云生活广场项目,并打出朝阳路商业航母的旗号。白云生活广场位于朝阳路中段。朝阳路不
The pregnane-X-receptor (PXR) regulates the expression of biotransformation enzymes and transporters for drugs and steroid hormones.Thereby, it influences c
In rabbits and rats with hemorrhagic and traumatic shock (TSh) there is a decrease in the level of glucocorticoid receptors (GR).Reduction in the GR content
五六年前的那段经历至今让我难忘: 尼泊尔故都Bhaktapur 的皇宫广场笼罩在夕阳如痴如醉的影调中,古老的建筑和街道,人们的生活状态似乎也停留在数百年前的世界中,然而贫穷并
据“链家”统计资料显示,2004年三季度北京二手房成交量相比二季度再度上涨28%,比去年同期上涨88%。之所以三季度北京二手房成交量继续火爆上涨,一方面要归功于政策的利好,比
这是一个大浪淘沙的年代,身处一个前狼后虎的处境,不得不面对一个你死我活的结局,对于很多代理行来说,属于他们的黄金时代已经一去不复返,他们所要考虑的不是掌握一个发展壮
Alzheimers disease (AD) is a neurodegenerative disease characterized by overproduction of β-amyloid peptides (Aβ) in the brain.The majority of these patie