Background: Understanding the situation of the cancer awareness which the patients undergone could lead to prognosis prediction of colorectal cancer (CRC).Methods: Subsets of 10 779 CRC patients were used to screen the risk factors from the Cancer Registry in Pudong New Area in cancer awareness, age, TNM stage, and gender.Survival of the patients was calculated by Kaplan-Meier method and Cox regression analysis.The views of cancer awareness in doctors and patients were surveyed by telephone or household.Results: After a median observation time of 1616 days (ranging from 0 to 4083 days) of 10779 available patients, 2 596 of the 4 561 patients with cancer awareness survived, whereas 2258 of the 5 469 patients without cancer awareness and 406 of the 749 patients without the information of cancer awareness died of the disease.All-cause and cancer-specific survival were poor for the patients without cancer awareness than those with (P < 0.001 for each, log-rank test).Cox multivariate regression analysis showed that cancer concealment had significantly lower cancer-specific survival (hazard ratio (HR) =1.299; 95 % confidence interval (CI): 1.200-1.407)and all-cause survival (HR =1.324; 95 % CI: 1.227-1.428).Conclusion: Cancer concealment, not only late-stage tumor and agedness, is associated with a poor survival of CRC patients.