【摘 要】
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目的 TGF-β1 is a cytokine with many biological functions.During the tumorigenesis,TGF-β1 has its two-side effect.In one handTGF-β1 promotes the apoptosis of tumor cells by inhibiting its cell cycle.On t
【出 处】
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2016中华医学会呼吸病学年会暨第十七次全国呼吸病学学术会议
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目的 TGF-β1 is a cytokine with many biological functions.During the tumorigenesis,TGF-β1 has its two-side effect.In one handTGF-β1 promotes the apoptosis of tumor cells by inhibiting its cell cycle.On the other hand,TGF-β1 helps the development andmetastasis of tumor cells by stimulating the epithelial-mesenchymal transition(EMT),tumor angiogenesis,and tumor immunesuppression.TGF-β1 can induce the autophagy of various tumor cells as well as normal cells.The autophagy is the highlyconservative “self-eaten” phenomenon,which plays a significant role in the process of TGF-β1 regulating hepatocellularcarcinoma cells.However,there is no research about the relationship between TGF-β1 and autophagy in lung cancer.Therefore,we aim to find whether TGF-β1 can induce autophagy in non-small lung cancer cells and to explore the association aboutbiological function between TGF-β1 and autophagy and its mechanism.
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