Biodegradable and injectable hydrogels have board applications in the fields of cell culturing,tissue engineering,drug delivery,and cell therapy,etc.Herein we report an inexpensive and facile method scheme to prepare a biodegradable and injectable polymer–liposome hydrogel with aldehyde modified xanthan gum(ALD-XA)and phosphatidylethanolamine(PE)liposomes as matrix material and crosslinking points,respectively.The hydrogel was formed through dynamic Schiff base linkages between aldehyde groups of ALD-XA and amino groups of PE liposomes.After mixing ALD-XA and PE liposome solutions,the xanthan gum-based liposome hydrogel could be rapidly prepared within 5 min at room temperature.Owing to the dynamic equilibrium of the Schiff base bonds,the hydrogel was responsive to various stimuli,including physical stimulus(thermalization),chemical stimulus(pH value),and biological stimulus(histidine).Additionally,the hydrogel could easily be biodegraded by papain as a result of the digestion of xanthan gum backbones by enzymes.After injection through a needle,the hydrogel pieces were regenerated into a complete homogeneous hydrogel,showing significant self-healing capability.Cells encapsulated in the as-prepared hydrogel can keep their excellent viability,indicating it is a carrier material suitable for three-dimensional(3D)cell culturing.These advantages suggest that the xanthan gum-based liposome hydrogel is a promising candidate to be applied as a smart cell carrier for cell therapy and a cell culturing scaffold for tissue engineering.