【摘 要】
：
Background: Porcine circovirus type 2 (PCV2), the causative agent of postweaning multisystemic wasting syndrome (PMWS), is a serious economic problem for the swine industry in China.In this study, we
【机 构】
：
Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China
论文部分内容阅读
Background: Porcine circovirus type 2 (PCV2), the causative agent of postweaning multisystemic wasting syndrome (PMWS), is a serious economic problem for the swine industry in China.In this study, we investigated the genetic variation of PCV2 in China using strains isolated from 2004-2008.Viruses were isolated from samples collected from pigs with multi-systemic lesions and clinical signs of PMWS from different regions of China, and the genomes of these viruses were sequenced.
其他文献
目的:建立HBV抗原特异性细胞毒性T细胞(cytotoxic Tlymphocytes,CTLs)介导的HBV转基因小鼠肝炎模型,探讨肿瘤诱导的髓源抑制性细胞(myeloid-derived suppressor cells,MDSCs)对HBV转基因小鼠中免疫介导肝损伤的抑制作用.方法:制备新鲜的HBV转基因小鼠肝脏匀浆,予普通小鼠腹腔注射,一周一次、连续四周,以诱导致敏小鼠(Sensitize
Human adenovirus (HAdV) is a relatively large non-enveloped dsDNA virus.The almost 55 serotypes infecting humans are grouped into six species (A-G).It might cause respiratory disease by viruses belong
Autophagy is a cellular catabolic process that sequesters cargo in double-membraned autophagosome and delivers the cargo to lysosomes to be degraded for recycling resource for cells.Autophagy plays im
由于RNA依赖的RNA聚合酶(RdRp)缺乏校正功能,RNA病毒种群以准种(quasispecies)形式存在。已有研究表明,RNA聚合酶的保真性提高即变异频率下降能够导致突变体病毒的毒力减弱。最近也有研究显示,聚合酶保真性降低的柯萨奇B3病毒的毒力也显著下降。
口蹄疫病毒(FMDV)的非结构蛋白常被用于免疫接种动物与自然感染动物的鉴别诊断。一些非结构蛋白虽然具有良好的免疫原性,但同时也存在着一定的局限性。如2C蛋白只对猪具有良好的免疫原性,3A蛋白检测口蹄疫感染性动物的敏感较低,3D蛋白在感染和疫苗接种动物体内均产生针对于其相当水平的抗体。因此,以上非结构蛋白都不适合做为FMDV感染鉴别诊断检的测性抗原。
病毒非编码RNA (noncoding RNA, ncRNA)在病毒-宿主相互关系中发挥重要作用.在本研究中,我们发现并鉴定了一种新的病毒ncRNA存在于禽传染性支气管炎病毒(infectious bronchitis virus,IBV)感染的细胞中.该ncRNA全长563个核苷酸(不包括poly(A)尾),主要源于IBV基因组的3端非翻译区.在它的5端,融合有源于IBV基因组5端的63个核苷酸
The encephalomyocarditis virus (EMCV) can cause acute myocarditis in young pigs or reproductive failure in sows.The BD2 Strain was isolated from the suspected piglets with EMCV in China.In order to es
Porcine circovirus type 2 (PCV2) is generally considered to be the primary causative agent of postweaning multisystemic wasting syndrome (PMWS), which has become a serious economic problem for the swi
Background: Porcine circovirus type 2 (PCV2) is associated with post-weaning multisystemic wasting syndrome (PMWS) in pigs.Currently, there is considerable interest in the immunology of PCV2, in parti
Background: The conserved motif 97RIRKVKV103 in the porcine circovirus type 2 (PCV2) capsid protein (Cap) was initially presumed to bea binding site for cell surface proteoglycans.As this motif later