【摘 要】
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Aim Multipotent neural stem cell (NSC) is a potential candidate treatment for central nervous system (CNS) injury because of their ability to compensate for neuronal damage.To maximize the regeneratio
【机 构】
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天津医科大学总医院骨科 南开大学医学院
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Aim Multipotent neural stem cell (NSC) is a potential candidate treatment for central nervous system (CNS) injury because of their ability to compensate for neuronal damage.To maximize the regeneration,it is necessary to regulate the fate determination of NSCs to produce more neurons and fewer astrocytes.Valproic acid (VPA) and all-trans-retinoic acid (ATRA),two clinically established drugs,induce neuronal differentiation and facilitate neurite outgrowth at the expense of astrocytic differentiation in NSCs.
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