NIFEVIROC,a New and Potent Small-molecule Inhibitor Targeted at the Human Immunodeficiency Virus Typ

来源 :2006中国天津世界艾滋病日科技会议 | 被引量 : 0次 | 上传用户:highbird51426
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  NIFEVIROC,a small molecular compound,is a proprietary drug candidate which is developed by TARGETDRUG and holds great promise in inhibiting HIV-1 replication in infected patients.Preclinical studies suggested that NIFEVIROC is a specific CCR5 antagonist determined by multiple receptor functional assays.In addition,NIFEVIROC demonstrated potent inhibition activity against HIV-1 entry into the target cells by effectively blocking the human CCR5 receptors on the cell membrane.Furthermore,NIFEVIROC showed strong antiviral activity against wide variety of HIV strains,including those multi-drug resistant mutants.Pharmacokinetic studies confirmed the oral bioavailability of NIFEVIROC,and its safety in various animal models in both acute and chronic states.
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