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Background Recent reports suggest that GAG triplet expansions of spinocerebellar ataxia type 2 and 3 (SCA2 and SCA3/MJD) genes (ATXN2 and MJD1) are the cause of typical levodopa-responsive Parkinson s disease (PD), several of which were found in patients of Chinese ethnicity.It is unclear whether ethnicity (or founder effects within certain geographical region) alone can explain such an association.Objectives To investigate the prevalence and chnical feature (s) of SCA2 and SCA3/MJD in patients with Parkinsonism in a Mainland Chinese population and to find the difference in the SCA2 and SCA3/MJD mutations between ataxic and parkinsonian phenotypes.