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The efficacy of amoxycillin clavulanic acid as antibiotic prophylaxis in surgery has been assessed in numerous clinical studies,chiefly in abdominal and gynaecological surgery.A meta-analysis of 21 trials covering 2685 patients given amoxycillin-clavutanic acid and 2220 patients given comparator regimens is presented.Monotherapy with amoxycillin clavulanic acid was as effective as the comparators,including combination regimens utilizing gentamicin or metronidazole,in preventing wound infections (median wound infection rates were 6% and 10% respectively).The antibacterial activity of amoxycillin-clavulanic acid covers the broad range of aerobic Gram-negative and anaerobic organisms that have a major role in postoperative infections.In addition,amoxycillin clavulanic acid may have benefits in terms of convenience,tolerance and cost.