【摘 要】
：
Previous research has indicated that suppressing the tumor cells by inhibiting the binding of MDM2 to p53 with chemical compounds is a worthy endeavor as a
【机 构】
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ZJU-ENS Joint Laboratory of Medicinal Chemistry,College of Pharmaceutical Sciences,Zhejiang Universi
【出 处】
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第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会
论文部分内容阅读
Previous research has indicated that suppressing the tumor cells by inhibiting the binding of MDM2 to p53 with chemical compounds is a worthy endeavor as a new therapeutic strategy for cancer.In hope of identifying novel p53-MDM2 binding inhibitors with higher potency and lower toxicity,a pharmacophore model was set up based on the structures of known p53-MDM2 binding inhibitors using Accelrys Catalyst package.
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