Pd-Catalyzed Carbonylative Csp3-H Cycloamidation of Ketoimines for Synthesis of Pyrido [1,2-a] Pyrim

来源 :第五届岭南有机化学论坛暨华南理工大学-兰州大学有机化学双边论坛 | 被引量 : 0次 | 上传用户:dolan525
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Transition metal-catalyzed C-X(X= C,N etc.) coupling reactions derived from imines are widely utilized in constructing kinds of nitrogen-containing compounds,but the carbonylation involving imines was rarely reported.Up to now,only Iwasawa ever developed a molybdenum-promoted carbonylative cyclization of ortho-haloarylimines,in which carbonylation insertion occurred through oxidative addition of Mo(0) to Csp2-halogen bond(Scheme 1a).Recently,Yoshikai reported that Pd(II) could directly catalyze the intramolecular oxidative cyclization of N-aryl ketoimine to construct indoles(Scheme 1b).
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