【摘 要】
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Cancer has become the top killer to human lives.Recently,transition metal based complexes with unique biochemical properties have emerged as promising anti-cancer agents,which may serve as alternative
【机 构】
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School of Chemistry and Materials Science,Nanjing Normal University,Nanjing,210023
【出 处】
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2018中西部地区无机化学化工学术研讨会
论文部分内容阅读
Cancer has become the top killer to human lives.Recently,transition metal based complexes with unique biochemical properties have emerged as promising anti-cancer agents,which may serve as alternatives of cisplatin and its derivatives.Meanwhile,cyclometalated complexes have been reported with the potential to overcome the long-term drug resistance[1].Herein,we have synthesized a cyclometalated iridium(Ⅲ)complex with an anthraquinone derivative from rhein(4,5-dihydroxyanthraquinone-2-carboxylic acid).Rhein is an natural product isolated from a traditional chinese medicine herb rhubarb,and has extensive pharmacological properties,for example,anti-bacterial,anti-viral,anti-inflammatory,anti-proliferative,anti-fibrotic and anti-tumor activities[2].Further studies are undergoing,such as the physical and chemical properties,its biological activities and anticancer mechanism.
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