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The ERRalpha receptor is an orphan member of the nuclear receptor family,which is related to the estrogen receptors but not modulated by estrogens nor by any known natural ligand.ERRalpha is highly expressed in osteoblasts (bone-forming cells),suggesting a role in the homeostasis of bone tissue.Our in vivo and ex vivo studies show a function of ERRalpha in regulating bone mineralization as well as osteoblast differentiation,suggesting that modulating the activity of ERRalpha could be of potential benefit against osteoporosis.On the other hand high ERRalpha expression is correlated to a poor prognosis in different types of cancers,including breast cancer.Our results show that ERRalpha regulates both proliferation as well as cell invasion and migration of various cell types.Again modulating ERRalpha may be beneficial against cancer.