Missense mutation within TP53 gene not only loses their tumor suppressive functions, but also gains new abilities that promote tumorigenesis.TGF-beta signaling play a dichotomous role in tumor progression,and it is widely believed that the Smad-dependent pathway is involved in TGF-beta tumor suppressive functions, whereas activation of Smad-independent pathways coupled with the loss of tumor suppressor function of TGF-beta is important for its pro-oncogenic effects.