Backgrounds The participating of clinical pharmacists has been demonstrated as a successful mode in western countries but preliminary in our country, studies show that the compliance rate was higher in the climc that pharmacists manage than others.We learned the global advance experiences and combined the situation of us, carry out works on some part of areas, and provide some experience for anticoagulant clinic management by pharmacists.Aims To explore a working mode of anticoagulant clinical pharmacists.Methods Following global advanced management mode, combined with situation of our hospital, we carry out works on these areas: 1.Inpatients anticoagulant drugs education management; 2.Dosing advise of anticoagulant drugs based on pharmacogenetics; 3.Outpatient follow-up clinics executed by physicians, nurses and pharmacists.All the work above explores a working mode for integrated anticoagulant pharmaceutical care.Results We have completed anticoagulant education on more than 40 patients, and pharmacogenetics based on dosing advisement for more than 130 till now.Conclusion The efficacy of anticoagulant drugs was influenced by many factors; the intervention of clinical pharmacist may provide a new mode of patients health care.