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Fas/FasL system can transmit intracellular apoptotic signal inducing cell apoptosis.However, Fas signal can also exert non-apoptotic function, except to the direct impact on tumor cells, Fas signal induces lung cancer tumor cells producing PGE2 and recruiting myeloid-derived suppressor cells.Activated CTL can induce and express high level of FasL, it is not clear that the effect of Fas activation initiated by FasL of CTL on apoptotic resistant tumor cells.We purified activated CD8+ T cell from OT-1 mice, determined the regulatory effect on tumor cells and explored the relevant mechanism.In this study, we found that CTL can promote tumor cells secreting PGE2 and increasing tumor cells chemoattracting effect of MDSC via Fas signal.The results suggest that CTL may participate the process of tumor immune evasion.In this study, we put forward a new mechanism in tumor escape research.It will bring benefit to explore a new idea about how to enhance bodys antitumor immune response through reducing negative immune respones to tumor derived from CTL via Fas signaling.