Magnetic nanoparticles(NPs)-based hyperthermia is a promising non-invasive approach for cancer therapy(1).However,the heat transfer efficiency of magnetic NPs would decrease sharply with the increase of distance(2).Therefore,it is challenging to improve the magnetic hyperthermia efficiency by exploring the higher performance magnetic NPs-based hybrid nanostructures.In the current study,its presented a straightforward in situ reduction method for the shape-controlled preparation of magnetite(Fe3O4)silver(Ag)hybrid NPs designed as magnetic hyperthermia heat mediators associating magnetically induced heating derived from Fe3O4 with anti-cancer effect derived from Ag.