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Objective To retrospectively analyze the curative efficacy of umbilical cord blood Transplanttation (UCBT) using total body irradiation (TBI)-based myeloablative conditioning regimen without antithymocyte globulin (TBI/Ara-c/CY w/o ATG) in adolescent and adult patients with high-risk hematological malignancies.Method Outcomes of forty-five consecutive adolescent and adult patients with high-risk hematological malignancies treated with TBI-based myeloablative UCBT without ATG in a single center between September 2006 and February 2012 were retrospectively analyzed,The conditioning regimen included TBI/Ara-c/CY:TBI 12GY (four fractionated) + Ara-C 8g/m2 (two days fractionated) + CY 120mg/kg (two days fractionated),and rhG-CSF was administered for myeloid leukemia by continuous infusion at a dose of 5μg·kg-1·d-1.Infusion of G-CSF was started 24 hours before the first dose of Ara-C and stopped at the completion of the last dose.