Previously, we identified miR-125b as a key regulator of the undifferentiated state of hair follicle stem cells.Here, we show that both in mouse and human, miR-125b is abundantly expressed, particular
The aberrant expression of microRNAs (miRNAs) plays roles in development, progression, metastasis and prognosis.MiR-1188 is located in Meg8 transcripts, which has been identifed as a maternally expres
Most HCC patients die from metastasis and recurrence.Emerging evidence suggests that EMT contributes to the promotion of tumor metastasis and recurrence.
We previously report that BMP2 mediates mild ER stress.The mammalian unfolded protein response (UPR) protects the cell against the stress of misfolded proteins in the endoplasmic reticulum (ER).Failur
MicroRNAs (miRNAs) participate in the regulation of myogenesis and muscle physiological function.Most skeletal muscles in vertebrates contain a mixture of fibertypes.
Small non-coding RNAs (ncRNAs) are important for the early embryonic development of mammalians, but little is known about their expression dynamics due to difficulties in obtaining large numbers of ce
CRISPR/Cas9是细菌和古细菌在长期演化过程中形成的一种适应性免疫防御,可用来对抗入侵的病毒及外源DNA.crRNA通过碱基配对与tracrRNA (trans-activating RNA)结合形成tracrRNA/crRNA复合物(gRNA),此复合物可引导Cas9核酸酶在与crRNA配对的序列靶位点造成DNA双链断裂.目前通过人工改造与设计RNA,理论上我们可以知道Cas9对大多数DN
Skeletal muscle injury activates satellite cells to initiate proliferation and differentiation to form new muscle fibers.miR-17-92 cluster is induced at the initial post-injury stage and thereafter st
microRNAs (miRNAs)是一类长度为18～23 nt的非编码小RNA,在转录后水平调控基因的表达,功能上涉及细胞分化、增殖、凋亡、胚胎发育和器官形成等过程.2012年,我们报道了一种灵敏特异的miRNA检测技术——S-Poly(T)法(Kang,PLoS One, 2012),本工作描述其升级版S-Poly(T) plus法.S-Poly(T) plus法将miRNA的多聚腺苷酸化及反
细胞自噬是细胞通过一系列复杂的过程将自身组分或者外来入侵者消化的过程，是维持细胞稳态和抵抗逆境的重要机制.自噬在脂肪细胞分化和肥胖过程中也起重要作用.我们在最近的研究中发现，在调控线粒体生成与能量代谢中起重要作用的转录辅因子Ppargc1b介入了脂肪细胞分化过程中的自噬调控，而Mir3 78a能通过抗衡Ppargc1b对自噬的影响增强脂肪细胞的分化.Mir3 78a位于Ppargc1b基因的第一个