定量药理学及其重点研究领域定量药理学以数学和统计学方法来描述、理解和预测药物的药动学和药效学行为,并对其中的信息的不确定性进行量化.群体药动学(PPK)研究药物相互 作用的方法 把合并药物作为一个二进制变量—1:有合并药物—0:没有合并药物将合并药物作为一个协变量估算参数(如CL)—合并给药后的清除率变化分数(fCL)评估药物相互作用—两种方法
研究背景作为食品添加剂作为食品添加剂PBPK/PD模型研究物质不良反应体内代谢——物质基础不良反应机制不良反应机制研究目的课题内容
新药研发速度的加快、中药制剂以及生物制品的发展,都使得不良反应监测再次成为热点问题。我国现行的ADR监测系统为自发呈报系统(spontaneous reporting system,SRS),在该系统的应用过程中及时收集到了大量的ADR报告信息,但也出现了比如数据信息堆积、数据分类困难、数据信息不标准等问题。因此,借助计算机编程和数据库语言进行ADR报告分析以及ADR信号监测成为新的发展趋势。
Physiologically based pharmacokinetic (PBPK) modeling holds great promise for anticipating the quantitative changes of pharmacokinetics in pediatric populations relative to adults, which has served as
Aim: Sepsis or septic shock is a severe complication after severe trauma or infection, its morbidity and mortality were still high although a great development in medicine and techniques recent years.
Aim: Two pore domain potassium channel TREK-1 has been shown to present in the mammalian heart, but the role of TREK-1 in heart is unclear.We aimed to elucidate the expressional and functional changes
Aim: Doxorubicin is a chemotherapeutic drug widely used to treat solid and haematopoietic tumours.Its clinical application is limited by its severe cumulative dose-related cardiotoxicity.Previous rese
Aim: The present study was designed to test the functional role of PDCD4 in cerebral ischemia reperfusion (I/R) injury and explored the cellular and molecular mechanisms involved in the pathogenesis o
Background: Increasing evidence suggests that innate immunity is involved in cerebral ischemia-reperfusion (I/R) injury, but the liable innate immune receptors have not been completely elucidated.Here
Aims: The purpose of the present study was to investigate the potential neuroprotective role of S-allyl cysteine (SAC) and to delineate its mechanism of action against cerebral ischemia in cellular an