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Using high-resolution array comparative genomic hybridization profiling, we demonstrated that the minimum region of recurrent amplification in the chromosomoe 1 q22 amplicon contained RAB25, a member of the RAS superfamily of small guanosine triphosphatase (GTPase), plays an important role in tumorigenesis in regulating tumor progression and aggressiveness.Gene amplification and mRNA expression are correlated with shorter overall survival and increase recurrence in breast cancer.In addition, RAB25 mRNA and protein appear to exhibit a subtype-specific pattern of expression with high levels of expression in estrogen receptor (ER)-and Her2-positive tumors, intermediate expression in basal tumors, and low absent expression in metaplastic breast cancers.Studies on Rab GTPases, along with their associated regulators and effectors, have revealed that Rab proteins are major regulators of intracellular vesicular transport and trafficking of proteins.Its role in endosomal transport, recycling of cell-surface receptors and signaling proteins presents a novel paradigm for the disruption of cellular pathways and promotion of tumor development and aggressiveness.