目的:探讨肺癌患者中肿瘤标志物多指标联合检测的意义。方法:采用微粒子免疫荧光分析法(MEIA),检测患者血清中的癌胚抗原(CEA)、癌抗原125(CA125)、癌抗原199(CA199)水平。结果:肺癌组三项指标均明显高于结核组和正常组,(P<0.01)。腺癌组CEA、CA125阳性率均显著高于鳞癌组和小细胞癌组(P<0.05)。结论:三项指标对不同组织类型肺癌均有一定的诊断价值,三项指标联合检测有明显的互补性,对肺癌的诊断提供可靠依据。 Objective: To explore the significance of multi-index combined detection of tumor markers in patients with lung cancer. Methods: The levels of carcinoembryonic antigen (CEA), cancer antigen 125 (CA125) and cancer antigen 199 (CA199) were detected by microparticle immunofluorescence assay (MEIA). Results: The lung cancer group of three indicators were significantly higher than the tuberculosis group and normal group (P <0.01). The positive rates of CEA and CA125 in adenocarcinoma group were significantly higher than those in squamous cell carcinoma and small cell carcinoma group (P <0.05). Conclusion: The three indexes have certain diagnostic value for different types of lung cancer. The three indexes are significantly complementary to each other and provide a reliable basis for the diagnosis of lung cancer.