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Purpose: We investigated implanting CT-guided 125I seeds to treat locally advanced non small cell lung cancer(NSCLC)after chemotherapy failure.Methods: From January 2005 to July 2010,we recruited 69 patients with locally advanced NSCLC who had each had 1st-line chemotherapy four to six times but had progressive disease; 34 received 125I seed implants with 2nd-line chemotherapy(Group A)and 35 received 2ndline chemotherapy only(Group B).