Recent studies have demonstrated the persistence of antibiotics in soil,especially in areas of vegetable culti-vation.However,there are very few studies of the influence of planting regimes on the levels of antibiotic pollution.This work introduces geographical-detector models to investigate the relationship between planting patterns(vegetable planting model,manure type and quantity,planting age,greenhouse area,and topographic elevation)and residual fluoroquinolones(FQs)in soil in a pilot project in Shouguang County,Shandong Province(the largest vegetable-producing area in China).The results led to the following findings.1.The vegetable planting model is the major determinant of the spatial stratification of FQin the soil.For example,the"cucumber-cucumber"model(growing cucumbers after cucumbers)has a three-fold power of determinant compared to the"pepper-melon"model(growing melons after peppers).2.Planting age(years with continuous vegetable cultivation)does not necessarily affect the spatial distribution of FQ owing to their relatively short degradation period.3.Inter-actions between risk factors were more significant than the individual factors for FQ pollution.In particular,the interaction between the vegetable planting model and amount of manure resulted in the highest pollution level.The findings of the present study make it possible to introduce effective and practical measures to alleviate pollution of soils by FQ in the study area.Adjustment of the vegetable cultivation models and application of chicken manure(less than 6 kg/m2 manure annually with a more dry than fresh manure)could be an effective and flexible approach to alleviate FQ pollution.