For several decades, Multiple Stage Flashing (MSF) has been the main stream in thermal seawater desalination process due to its stable and robust performance. In the Middle East region, MSF units of large capacity evaporators have generally been supplied. Meanwhile, Multiple Effect Desalination (MED) process with Thermal Vapor Compression (TVC) has recently been receiving attention because of the lower energy consumption.Dynamic simulation of thermal desalination plant could be used to validate plant operation before and after the plant design step. Also, it is expected to be helpful for understanding the dynamic behavior of processes under various conditions.