Foxtail millet (Setaria italica L.) is cultivated around the world for human and animal consumption.There is no suitable herbicide available for weed control in foxtail millet fields during the post-emergence stage.In this study, we investigated the effect and safety of the post-emergence herbicide tribenuron-methyl (TBM) on foxtail millet in terms of grain yield and quality using a split-plot field design.Field experiments were conducted using two varieties in 2013 and 2014, i.e., high-yielding hybrid Zhangzagu 10 and high-quality conventional Jingu 21.