To evaluate the safety, efficacy, and potential advantages of self-retaining barbed suture partial nephrectomy (SRBS-PN) compared with conventional suture.Relevant studies comparing the safety and efficacy of SRBS-PN to conventional suture PN were identified through a literature search using MEDLINE, EMBASE, and the Cochrane Library.The outcome measures included baseline characteristics, primary outcomes, and secondary outcomes.Eight studies (216 cases and 247 controls) were included.No significant differences between the two groups were detected in any of the baseline variables.SRBS provided a significantly lager decrease in warm ischemia time (WIT) (mean difference [MD],-7.08;95％ confidence interval [CI],-8.36 to-5.81, pp＜ 0.001), lower complication rates (odd ratio [OR], 0.49;95％CI, 0.25 to 0.93, p=0.03), and a larger decrease in estimated blood loss (MD,-47.62;95％CI,-56.78 to-38.47, p＜ 0.001) than conventional suture.No significant differences were detected between the two groups in other outcomes of interest.In early experience, SRBS is associated with a shorter WIT and comparable postoperative renal function preservation, and therefore represents an attractive option for performing renorrhaphy during PN.Given that inherent limitations in retrospective studies may prevent definitive conclusions, future well-designed RCTs are required to confirm these findings.