【摘 要】
：
Fibroblast growth factor 23 (FGF23) is a circulating factor that plays critical roles in phosphate and vitamin D metabolism.FGF23 is predominately produced by osteocytes/osteoblasts and exerts its bio
【机 构】
：
Laboratory of Endocrinology and Metabolism,West China Hospital,Sichuan University
【出 处】
：
中华医学会第十二次全国内分泌学学术会议
论文部分内容阅读
Fibroblast growth factor 23 (FGF23) is a circulating factor that plays critical roles in phosphate and vitamin D metabolism.FGF23 is predominately produced by osteocytes/osteoblasts and exerts its biological functions by interacting with FGFRklotho complexes.Major functions of FGF23 are to suppress the expressions of NPT2aand NPT2b in the renal proximal tubular cells and consequently can increase urinary phosphate excretion.
其他文献
Normal brain development requires thyroid hormone at specific stages.Severe hypothyroidism during neonatal development leads to irreversible impairment in neural differentiationand migration, as well
Background Oxidative stress has been linked to osteoporosis.Uric acid (UA) is a strong endogenous anitoxidant.The purpose of the study is to exam the association between serum UA levels and bone miner
目的:本研究旨在应用NAFLD Fibrosis Score(NFS)评分系统初步估计合并非酒精性脂肪性肝病(Non-alcoholic fatty liver disease,NAFLD)的住院2型糖尿病患者(Type2diabetes mellitus,T2DM)中进展性纤维化(stage＞2)的患病状况,并对T2DM患者进展性纤维化的相关危险因素进行初步分析.
目的:腹腔镜减重手术前需要有效的缩小肥大的肝脏,可以减少手术的难度及并发症.但是目前此类研究几乎为空白.本研究拟在研究在同等程度减重的情况下短期低碳水化合物低热量饮食,长期低热量饮食以及高碳水化合物高热量饮食对肝脏体积的影响.
Objective Previous studies have proved that GLP-1 had cardiovascular protective effects by directly acting on cardiovascular system or by improving metabolism, which are both believed to be mediated a
Deficiency of beta-cell mass and failure of islet function are major characteristics in both type 1 and type 2 diabetes.Therefore, endogenous beta-cell mass restoration and islet function reconstructi
Objective AGEs is one of the pathogenic factors of DN,and our previous work has suggested that AGEs may play a central role in the pathogenesis of glomeruloselerosis.The aim of this study is to furthe
Background and Objective The aim of this study is to test the hypothesis that elevated levels of serum leptin and interleukin-6 (IL-6) during the first postpartum year may be related to the occurrence
背景:西方国家绝大多数原发性甲旁亢为无症状的患者.甲状旁腺癌的发病率低于1％,但最近有上升趋势.近10年中国原发性甲旁亢的临床表现的变化仍不清楚.方法:本研究分析了2000年至2010年在上海瑞金医院就诊的249名原发性甲旁亢患者的临床资料.
Graves disease (GD), with recent data showing a prevalence of hyperthyroidism up to 1.3％ (0.5％ clinical and 0.7％subclinical) in the U.S.and 0.25～1.09％ in China, is one of the most common autoimmune di