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The effect of increasing nano-sizedβ-tricalcium phosphate(β-TCP) contenton biological performance of polylactic acid (PLA) composite scaffold was investigated by in vitro degradation and in vivo model of beterotopic bone formation.Nano-sized β-TCP was prepared by wet grinding method,PLA/nano-sized β-TCP scaffold with increasing β-TCP (0 ~50wt %)contents were fabrtcated by freeze-dring method.