论文部分内容阅读
Biguanides are found widely as core structures in a large variety of compounds that exhibit important biological activity[1].
Copper-Catalyzed Synthesis of Biguanide Derivatives
【摘 要】
：
Biguanides are found widely as core structures in a large variety of compounds that exhibit important biological activity[1].
【机 构】
：
College of Pharmaceutical Science,Zhejiang University of Technology,Hangzhou 310014,PR China
【出 处】
：
第十四届全国均相催化学术讨论会
【发表日期】
：
2015年7期
其他文献
以顺铂为代表的金属抗肿瘤药物与DNA 形成交联或单功能复合物，导致DNA 双螺旋结构扭曲，进而抑制DNA 复制、转录，诱导细胞凋亡或坏死1.但是，人们对肿瘤细胞如何应答DNA 的金属药物损伤，启动下游的信号转导仍然知之甚少.
涉火案件中助燃剂残留物的检验至关重要，同时也一直是法庭科学领域的难点.助燃剂本身成分复杂，组分多变，火场燃烧和检材放置挥发会导致其组分发生很大变化，部分轻组分可能完全消失1.
Design and analysis clinical trials with a biomarker defined sensitive subgroup:A case study of NCIC
Recent advances in molecular biology promise biomarkers that may provide insights into the etiology of cancer.Targeted therapies aimed at the molecular pathways involved in oncogenesis have led to dev
会议
Bias-corrected Hierarchical Bayesian Classification with a Selected Subset of High-dimensional Featu
Class prediction based on high-dimensional features has received a great deal of attention in many areas.For example,biologists are interested in using microarray gene expression profiles for diagnosi
会议
过渡金属催化偶联反应是构建C-C 键的一种强大而有效的方法,2010 年,Heck,Nigishi,Suzuki 因其在偶联方面的贡献而共获诺贝尔化学奖.
采用不同形貌、比表面积和孔径大小的介孔硅胶为载体,利用化学键合法将离子液体负载在硅胶上,制得硅胶固载化酸性离子液体.利用N2 吸脱附、红外光谱(FT-IR)、热重分析(TG)、扫描电镜(SEM)、X 射线光电子能谱(XPS)等手段对催化剂进行表征,说明离子液体已成功键合在硅胶载体上.
Bromination of arenes is an important chemical transformation because the resulting products often serve as the electrophilic coupling partner for the cross-coupling reactions to synthesize various cl
会议
香豆素存在于许多天然产物和药物中,因极具合成原料价值性而被应用于材料化学中.传统制备3-芳基香豆素类物质主要通过以下五种方法:(1)利用水杨醛和苯乙酸或者芳基乙腈进行缩合反应[1];(2)钯催化的芳基卤化物或芳基硼酸进行交叉偶联反应成简单的香豆素类物质[2];(3)钯催化羰基化反应[3];(4)碱促进的芳炔类、丙二酸酯、DMF 三组分的偶联反应[4];(5)带有取代基色酮的氧化水解[5].
本文报道了一种铜促进的sp2C-H 键断裂形成C-S 键以合成二芳基二硫醚的方法.该反应体系中不需要各种添加物及配体,对各种官能团都有较好的适用性,可推广应用到苯并喹啉、2-苯基喹啉、吲哚等相关含氮杂环化合物.
Asymmetric hydrogenation with transition-metal complexed bearing chiral ligands is a powerful approach to synthesize chiral substances from unsaturated starting materials,and thus the design and devel