【摘 要】
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Objective: Our studies were conducted to investigate the clinical and functional significance of tumorassociated macrophages (TAMs) in cervical tumor angiogenesis and progression.Methods: We performed
【机 构】
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Department of Obstetrics and Gynecology,Union Hospital,Tongji Medical College,Huazhong University of
【出 处】
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2014中国医师协会妇产科医师大会
论文部分内容阅读
Objective: Our studies were conducted to investigate the clinical and functional significance of tumorassociated macrophages (TAMs) in cervical tumor angiogenesis and progression.Methods: We performed immunohistochemical staining in 90 cervical samples (38 invasive squamous carcinomas of uterine cervix,27 cervical intraepithelial neoplasms Ⅲ,and 25 normal cervix).Results: We found that the increase in macrophages in tumor stroma is significantly associated with increased microvessel density (MVD) in human cervical cancer (P<0.01).And increased MVD are associated with FIGO stage in human early cervical cancer.MVD in all cancer regions (including cancer nests,cancer stroma,peritumor and paratumor) in cases with FIGO stage Ⅱa were significant increased compared with those in cases with FIGO stage Ⅰa and Ⅰb (each P<0.05).Conclusion: Taken together,the results suggest that TAMs promote tumor-induced angiogenesis and tumor progression in cervical cancer.
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