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5. Simvastatin reduces deposition of plaques via high-fat diets in APPswe/PS1dE9 transgenic mice

Simvastatin reduces deposition of plaques via high-fat diets in APPswe/PS1dE9 transgenic mice

来源 :2nd International Neural Regeneration Symposium(INRS2012)(第二 | 被引量 : 0次 | 上传用户：tianchaoguoshi

【摘 要】

：

Pathogenesis of Alzheimers disease (AD) involves overproduction of extracellular amyloid beta (Aβ), neurofibrillary tangles, and diffuse loss of neurons.Epidemiological data linked hyperlipoidemia and

【作 者】

：

Jianfeng Wang Xuying Liu Li Zhang Ying Zhang Qiong Wu Haiying Chu 

【机 构】

：

Department of Neurology, Affiliated Dalian Central Hospital of Dalian Medical University, Dalian 116

【出 处】

：

2nd International Neural Regeneration Symposium(INRS2012)(第二

【发表日期】

：

2012年8期

【关键词】

：

Alzheimer's disease amyloid beta nuclear receptor PPAR γ β-and γ-secretase 

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　　Pathogenesis of Alzheimers disease (AD) involves overproduction of extracellular amyloid beta (Aβ), neurofibrillary tangles, and diffuse loss of neurons.Epidemiological data linked hyperlipoidemia and AD suggesting high cholesterol and high-fat diet is a risk factor of AD.

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