【摘 要】
：
Bone marrow stromal cell antigen 2 (BST-2) inhibits the release of HIV-1 and other enveloped viruses from the cell surface.HIV-1 Vpu binds to BST-2 through an interaction between transmembrane domains
【机 构】
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Institute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing, China
【出 处】
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第七届国际分子模拟与信息技术应用学术会议
论文部分内容阅读
Bone marrow stromal cell antigen 2 (BST-2) inhibits the release of HIV-1 and other enveloped viruses from the cell surface.HIV-1 Vpu binds to BST-2 through an interaction between transmembrane domains (TMD) of the two proteins and induces the downregulation of cell surface BST-2, thereby counteracting its antiviral activity.In this study, we designed and prepared a modified peptide BST2-TM-P 1, which include the sequence of BST-2 TMD, keeping its property competing with BST-2 to bind with Vpu.Biological assay results indicate BST2-TM-P1 could increase the BST-2 level at the cell surface in Vpu dependent manner and significantly inhibit the replication of HIV-1 virion.Our studies indicate that blocking the interaction of Vpu and BST-2 is an effective way to combat HIV-1 infection.(C) 2014 Wiley Periodicals, Inc.Biopolymers
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