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  5. AGE-breaker ALT-711 plus insulin could restore erectile function in streptozocin-induced type 1 diab

AGE-breaker ALT-711 plus insulin could restore erectile function in streptozocin-induced type 1 diab

来源 :GTAUF2014 & APSMHA2014第六届长城泌尿男科转化医学论坛暨第七届亚太男性健康与抗衰老研究学会年会 | 被引量 : 0次 | 上传用户：Colo
【摘 要】
：
Introduction: The interaction between advanced glycation end-products (AGEs) and its receptors for AGEs (RAGEs) elicits oxidative stress and mediates the development of erectile dysfunction (ED).ALT-7
【作 者】
：
Lin Wang Wenjie Tian Zaid Uwais Guangyong Li Huixi Li Ruili Guan Zhezhu Gao Zhongcheng Xin 
【机 构】
：
Andrology Center, Peking University First Hospital, Peking University,Beijing, China
【出 处】
：
GTAUF2014 & APSMHA2014第六届长城泌尿男科转化医学论坛暨第七届亚太男性健康与抗衰老研究学会年会
【发表日期】
：
2014年11期
【关键词】
：
AGE-breaker ALT-711 insulin erectile dysfunction (ED) 
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Introduction: The interaction between advanced glycation end-products (AGEs) and its receptors for AGEs (RAGEs) elicits oxidative stress and mediates the development of erectile dysfunction (ED).ALT-711, an AGE cross-link breaker, has the therapeutic potential for ED but has been less intensively investigated.Aim: The aim of this study was to investigate the effects of an AGEs breaker 3-phenacyl-4, 5-dimethylthiazolium chloride (ALT-711) plus insulin on erectile function in streptozocin (STZ)-induced type 1 diabetic rats.
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