Survival rates following in-hospital and out-of-hospital cardiac arrest remain disappointingly low.Organ injury caused by ischemia and hypoxia during prolonged cardiac arrest is compounded by re-perfusion injury that occurs when a spontaneous circulation is restored.A bundle of procedures, which may need to be administered simultaneously, is required.The procedures include prompt identification and treatment of the cause of cardiac arrest, a definitive airway and ventilation together.Additional benefit is possible with appropriate forms of early goal-directed therapy and achieving therapeutic hypothermia within the first few hours, followed by gradual rewarming and ensuring glycaemic control within a range of 6-10 mmol/L.All these would be important and need to be continued for at least 24 hours.Previous studies have showed that the effects of Shen-Fu injection (SFI) are based on aeonitine properties, supplemented by ginsenoside, which can scavenge free radicals, improve energy metabolism, inhibit inflammatory mediators, suppress cell apoptosis, and alleviate mitochondrial damage.SFI, like many other complex prescriptions of traditional Chinese medicine, was also found to be more effective than any of its ingredient used separately in vivo.As the post-resuscitation care bundle is known to be, the present article focuses on the role of SFI playing on the post-resuscitation care bundle.