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Genetics-based approaches have been developed to control transmission of vector-borne pathogens.Strategies for both population suppression and population replacement of mosquitoes have benefitted from the development of transgenesis,site-specific recombination,insulator DNA sequences,specific gene ablation and targeted effector molecules.Advances in the development of vector-based genetic control strategies for preventing malaria parasite and dengue virus transmission have resulted in tools that in laboratory trials either suppress completely mosquito populations or render them incapable of transmitting the pathogens.The latest research will be presented on the development of flightless-female strains for population suppression,pathogen-resistance genes for preventing the transmission of human malaria parasites by the Asian vector mosquito,Anopheles stephensi,and dengue viruses by Aedes aegypti.Models and outcomes for the effective practical use of these strains also will be discussed.