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The induction of antigen specific memory CD8+ T cells in vivo is very important to new vaccines against infectious diseases.In the present study, we aimed to evaluate the immune responses of peptide-specific CD8+ T cells induced by HLA-A*0201 restricted severe acute respiratory syndrome-associated coronavirus (SARS-CoV) S epitopes plus CpG ODN, PolyI∶C and R848 as adjuvants.Furthermore, the generation,distribution and phenotype of long-lasting peptide-specific memory CD8+ T cells were assessed by ELISA,ELISPOT and FACS.Our results showed that antigen specific CD8+ T cells were elicited by HLA-A*0201 restricted SARS-CoV S epitopes.