In the present studies,a novel hydrogel-grafted fabrics embedding of berberine nanosuspension was developed for the treatment of infected wound.Hydrogel-grafted fabrics (HGFs) was prepared by graft copolymerization of N-isopropylacrylamide (NIAAm) and alginate using ceric ammonium nitrate as initiator.Berberine nanosuspension was prepared and embedded in the HGFs to achieve sustained drug release.The prepared HGFs embedding of berberine nanosuspension was characterized by Fourier transform infrared spectroscopy (FT-IR),scanning electron microscopy (SEM),and swelling degree studies.FT-IR revealed that berberine was embedded into the matrix of HGFs,rather than on the surface.SEM showed that a thin hydrogel layer was formed on the surface of nonwoven fibers.The swelling study showed that HGFs was water absorbing with reversible temperature sensitivity.The drug release study demonstrated that HGFs could be used as a sustained drug delivery system of hydrophobic compounds.The berberine nanosuspension embedded HGFs was further investigated in an animal infected wound model and was found to be a very promising wound healing dressing for the treatment and healing of infected wounds.